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tecovirimat will enhance the level or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Tecovirimat is usually a weak inhibitor of CYP2C8 and CYP2C19. Keep an eye on for adverse consequences if coadministered with sensitive substrates of those enzymes.Outcome of coadministration of the twin CYP3A4 and CYP2C1